Best QB, RB & WR Matchups of Week 10

Browse our Game and Player Matchup Dashboards to identify advantage insights and positional mismatches across the board in Week 10. Our Player Matchup Dashboards offer a wide array of data and analysis, including explosive runs and passes, red zone carries, targets and receptions, YAC, receptions, QB rushing yards, RB receiving yards and more.

Best QB Matchups

Player Matchup Dashboard: Passing YPG

  • Brock Purdy (O260.5 passing yards) and the 49ers will face a Bucs’ defense ranks 29th in EPA/play, 27th in YPP, 30th in passing YPG and 28th in passes of 10+ yards. Recent quarterbacks have torched the Bucs, including Patrick Mahomes (34-44, 291 passing yards, 3 TD’s), Kirk Cousins (23-29, 276 yards, 4 TD’s / 42-58, 509 passing yards, 4 TD’s) and Lamar Jackson (17-22, 281 passing yards, 5 TD’s) over the L5 weeks.
  • Kirk Cousins (O240.5 passing yards) will face a Saints’ secondary that ranks 27th in passing YPG and 24th in YPA. Cousins leads an Atlanta passing attack that ranks 6th in passing YPG, 7th in YPA and 3rd in passes of 10+ yards, while the Saints just traded their best CB in Marshon Lattimore to the Commanders and will be without another starting corner in Kool-Aid McKinstry. Pat Mahomes (28-39, 331 yards), Baker Mayfield (24-36, 325 yards, 4 TD’s) and Justin Herbert (20-32, 279 yards, 2 TD’s) have cleared this number over the L5 weeks against NO, while the other 2 QB’s they faced were Bo Nix and Bryce Young.
  • Sam Darnold (O243.5 passing yards) and the Vikings will face one of the worst secondaries in the league in Jacksonville on Sunday. The Jags rank 30th in EPA/play and YPP allowed, 31st in passing YPG, 31st in YPA and 28th in passes of 10+ yards allowed and have been torched by Josh Allen (23-30, 263 yards, 4 TD’s), CJ Stroud (27-40, 345 yards, 2 TD’s), Joe Flacco (33-44, 359 yards, 3 TD’s) and Caleb Williams (23-29, 226 yards, 4 TD’s, 1 INT) in the last month and a half. Darnold just threw for 290 yards and 3 TD’s on 28-34 passing against Indy’s suspect secondary and has cleared this number in 3 of his L5 games.

Best RB Matchups

Player Matchup Dashboard: Rushing YPG

  • Saquon Barkley (O93.5 rushing yards) will face one of the worst run defenses in football in the Cowboys that ranks 31st in rushing YPG, 27th in YPC, 24th in runs of 10+ yards that has allowed SF (223 rushing yards), DET (184 rushing yards) and BAL (274 rushing yards) to roll over them over the last month and a half. Barkley is averaging nearly 116 rushing YPG this season and leads the league in runs of 10+ yards and trails only Derrick Henry in runs of 20+ yards. He has cleared this number in 6 of 8 games this season and in each of his L3 games against superior run defenses.
  • Najee Harris (O66.5 rushing yards) has been excellent over the L3 weeks in a stretch where he is averaging 18 carries and 107+ rushing YPG. Harris is tied for 3rd in the league in runs of 20+ yards and will now line up against a Commanders’ run defense that ranks 28th in rushing YPG, 30th in YPC and 31st in runs of 10+ yards. D’Andre Swift (18 carries, 128 yards, 1 TD), Derrick Henry (24 carries, 132 yards, 2 TD’s) and James Conner (18 carries, 104 yards, 1 TD) have all posted 100+ yards in 3 of the Commanders’ L5 games.
  • James Cook (O65.5 rushing yards) matches up against a Colts’ run defense that ranks 30th in rushing YPG allowed and 32nd in runs of 10+ yards. Cook has been a bit of a boom or bust candidate this season but has cleared this number in 2 of his L4 games and should be in line for touches and productivity against an Indy defense that has allowed Joe Mixon (25 carries, 102 yards, 1 TD), De’Von Achane (15 carries, 77 yards), Tony Pollard (17 carries, 93 yards, 1 TD) and Tank Bigsby (13 carries, 101 yards, 2 TD’s) to clear this number comfortably in 4 of the L5 weeks.

Best WR Matchups

Player Matchup Dashboard: Receiving YPG

  • Justin Jefferson (O92.5 receiving yards) ranks 2nd in the league in receiving YPG and should be the top target for a Minnesota passing attack that will face Jacksonville secondary that ranks 31st in passing YPG, 31st in YPA and 28th in passes of 10+ yards allowed. Jefferson is averaging 7.5 receptions, 9 targets and 126 receiving yards over the L2 weeks and is averaging nearly 98 receiving YPG on the season. He leads the league in both receptions of 10+ yards and 20+ yards and will face a Jags’ defense that ranks 31st in passing TD’s allowed.
  • George Kittle (O61.5 receiving yards) continues to be the steady presence in SF’s passing game in 2024 and is averaging nearly 72 receiving YPG. Kittle is averaging 6.3 receptions per game, 8 targets and nearly 86 receiving YPG over the L4 weeks, has caught 4 TD’s in that span and has cleared this number in 3 of his L4 games, while the Bucs rank 30th in TE receiving yards allowed and have been exposed by Travis Kelce (14 receptions, 100 yards) and Kyle Pitts (4 receptions, 91 yards, 2 TD’s) in the L2 weeks.

Head over to our Dashboard section of the site to comb through game matchup dashboards for every game on the board in Week 10, and browse our Player Matchup Analysis dashboards to optimize your DFS / FF lineups and target the player prop markets.

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